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West Nile Virus
Basic Questions
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1. What is West Nile virus?
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West Nile virus is a mosquito-borne virus first identified in the West Nile region of Africa in 1937. The virus has caused outbreaks of disease in Africa, Asia, Eastern Europe and the Middle East since then but it did not appear in the United States until 1999. After first being discovered in birds and people in the metropolitan New York area, it has since spread westward across the US and into Canada and Mexico. In October, 2006, West Nile virus was detected in King County for the first time. Five crows and a hawk tested positive for West Nile virus, but there were no human cases reported to have been acquired in King County. In 2006, however, Washington State had its first human cases when West Nile virus fever was diagnosed in residents of Pierce County (2 cases) and Clark County (1 case).
West Nile virus can infect humans, birds, mosquitoes, horses and other animals. Birds become infected with West Nile virus and carry the virus in nature. Mosquitoes become infected after feeding on infected birds. People bitten by a mosquito carrying West Nile virus may have no symptoms at all or they may become ill with symptoms ranging from mild to severe. The less serious form is called West Nile fever, a flu-like illness that may last from a few days to several weeks. In the more severe forms, West Nile virus affects the nervous system causing swelling and inflammation of the brain or covering of the spinal cord (called neuroinvasive disease) and may result in paralysis and death.
2. What are the human health effects of West Nile virus infection?
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Fortunately, most people who become infected with West Nile virus do not get sick--their body fights off the infection and protective antibodies develop. About 20% (1 person out of 5) develop West Nile fever with symptoms that may include fever, muscle aches, fatigue, headache, rash, and joint pain. Some people with West Nile fever are quite ill for up to several weeks and may see their doctor, but hospital care is not usually needed.
Less than 1 percent (about 1 in every 150) of persons who become infected with West Nile virus develop the more serious neuroinvasive form of the disease. Types of neuroinvasive disease include: West Nile encephalitis, West Nile meningitis, and West Nile meningoencephalitis. Encephalitis refers to inflammation of the brain. Meningitis is inflammation of the membrane covering the brain and spinal cord. Meningoencephalitis is a combination of the two syndromes. Symptoms may include fever, neck stiffness, confusion, disorientation, coma, tremors, convulsions, muscle weakness, and paralysis.
Persons who survive West Nile neuroinvasive disease may have long-term symptoms, but recovery from the milder forms of infection is usually complete. It is believed that once someone has had an infection caused by West Nile virus they develop long-term protection against being infected again.
3. How many human cases of West Nile virus occurred last year?
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In 2006, there were over 4,000 cases of West Nile virus illness reported in the US. This is a significant increase in cases compared to 2005 with 3,000 reported cases and 2004 with 2,539 cases. Of the 4,180 human cases reported for 2006 (as of 1/3/07), 61% had West Nile fever and 34% had neuroinvasive disease (in 5% the illness type was not reported). States with the highest number of cases in 2006 included Idaho, Colorado, Texas, Nebraska, and California. Idaho was particularly hard hit with about 1,000 residents reported with West Nile virus illness.
4. How many people have died of West Nile virus infection?
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In 2006 in the US there were 149 deaths reported due to West Nile virus disease, a significant increase compared to the 119 deaths recorded in 2005 and 100 deaths in 2004. Most deaths due to West Nile virus are among older people, with the median age of persons who died being about 75 years (median age means that half the persons who died were older than 75 and half were younger). However, death has occurred in all age groups from infants to the very elderly.
5. Are there persons who are at greater risk of developing more severe illness?
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Yes. The risk for more serious illness starts to increase after about age 50. In 2005, the median age of persons who developed the more serious neuroinvasive form of the disease was 57 years and the median age of those who died was 75 years (median age means that half the individuals were older and half were younger). Children are not at greater risk than young- or middle-age adults. Pregnancy is not known to increase the risk of developing the severe forms of West Nile virus infection, however there have been cases a small number of cases where a pregnant mother contracted West Nile virus and passed it to her unborn baby.
6. How is West Nile Virus transmitted?
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West Nile virus is transmitted by the bite of a mosquito. Mosquitoes become infected when they feed on birds carrying the virus. When the mosquito takes a blood meal from the infected bird, the virus becomes located in the salivary gland of the mosquito. Then when the mosquito bites a human or animal, the mosquito injects the virus into its victim. Persons who become ill develop symptoms 3 to 14 days after infection. The West Nile virus remains in infected individuals for a relatively short time and does not cause chronic infections.
West Nile virus is not transmitted directly from person-to-person except for rare cases attributed to blood transfusion or organ transplantation. It is also not transmitted from animal-to-person except in very rare instances related to occupational exposure. There is no evidence that persons can become infected from eating meat from a West Nile virus infected bird or other animal.
7. Can I get a West Nile virus infection from a blood or organ donation?
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Although rare, West Nile virus has been transmitted through transfusions of whole blood or blood components such as plasma or platelets. Blood component suppliers are taking preventative measures to screen out blood donors who may have been infected with West Nile virus. A laboratory test for West Nile virus has been in use for screening blood donors since July 2003. There have been documented instances of West Nile virus transmission by organ transplantation, but the risk of this is extremely low.
8. Are pets and domestic animals at risk of West Nile virus?
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Fortunately, clinical illness due to West Nile virus is rare in dogs and cats, and chickens are resistant as well. Persons with pet birds should be careful to protect them from mosquito bites. Horses and other equines like mules and donkeys are susceptible to West Nile virus infection and severe illness and death can result. An equine West Nile virus vaccine is available and horse owners are strongly encouraged to consult with their veterinarian about immunization. Horses will also benefit from mosquito control efforts.
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